Fluorine in Medicinal Chemistry and Chemical Biology ? E-books PDF ...

Publisher: Wiley-Blackwell Issue: 1 Pages: 640 years Year: 2009 ISBN-10: 1405167203 ISBN-13: 9781405167208 pharmacy, pharmacy, chemistry, industrial technology and exceptional potential of the molecules containing fluorine in medicinal chemistry and chemical biology was by researchers outside the traditional fluorochemicals and a new wave of fluorine chemistry is expanding its biomedical recognized borders. Included with many of the top-selling drugs worldwide critical fluorine atoms, the incorporation of fluorine in drug development has lead to a significant process in biomedical research, particularly for drug design and discovery and development. The focus on the unique and important role that fluorine plays in medicinal chemistry and chemical biology, reviews this book, the recent progress and perspectives in this rapidly evolving field. Topics include: the discovery and development of fluorine-containing drugs and drug candidates. New and effective methods of synthesis in medicinal chemistry and optimization of fluorine-containing drug candidates. Structural biology and chemistry of fluorinated amino acids and peptides. Fluor labels as probes in the study of metabolism, protein engineering, and clinical diagnosis. Application of 19F NMR spectroscopy in biomedical research. An appendix provides a valuable overview of all drugs containing fluorine, which was approved by the U.S. Food and Drug Administration, including information on the structure and drug action plans. Fluorine in medicinal chemistry and chemical biology will serve as an excellent reference for graduate students and researchers from academia and industry, the fluoride in biomedical research do.

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